The NFL season is still nearly two months away, but a handful of bets for Week 1 are already gaining traction among fans.

Detroit Lions, San Francisco 49ers open thing up for other contenders in NFC As the 49ers and Lions were dropping their first games of the season, other NFC teams continued to impress.

Even as the misfortune mounts, the 13-2 Lions are road favorites against the 6-9 San Francisco 49ers.

This will be the first time the Lions and 49ers face off since Week 1 of the 2021 regular season, where San Francisco defeated Detroit 41-33 in the first game of the Dan Campbell, Brad Holmes era.

Predictions and picks for the 2024 NFL Week 1 matchup between the San Francisco 49ers and New York Jets.

San Francisco 49ers quarterback Brock Purdy celebrates with tight end George Kittle after scoring a touchdown in the 49ers' 40-34 loss to the Detroit Lions in Santa Clara, California, on Monday ...

The San Francisco 49ers may have to start a few players that many would not expect them to.

The NFL returns with an action-packed Week 1. Here is the full schedule, along with kickoff times and TV networks.

These rankings are voted on each week by hosts of the Locked on NFL podcasts, giving a look at who is trending up and trending down throughout the 17 week season.

Predictions and picks for the 2022 NFL Week 1 matchup between the San Francisco 49ers and Chicago Bears.

Predictions and picks for the 2024 NFL Week 1 matchup between the San Francisco 49ers and New York Jets.