The NFL season is still nearly two months away, but a handful of bets for Week 1 are already gaining traction among fans.

The San Francisco 49ers and Detroit Lions met in last year’s NFC Championship Game. ... Each one suffered their first loss of the season after big Week 1 wins.

This will be the first time the Lions and 49ers face off since Week 1 of the 2021 regular season, where San Francisco defeated Detroit 41-33 in the first game of the Dan Campbell, Brad Holmes era.

If San Francisco is to pull off the Monday night upset, it’ll need a colossal game from its defense. Leonard Floyd leads all pass rushers with 8.5 sacks. Fred Warner is still a menace at linebacker.

San Francisco 49ers quarterback Brock Purdy celebrates with tight end George Kittle after scoring a touchdown in the 49ers' 40-34 loss to the Detroit Lions in Santa Clara, California, on Monday ...

SAN FRANCISCO — The first week of the 2023 NFL season is in the rearview mirror, featuring a handful of surprising upsets, big blowouts, exciting rookie debuts, and unfortunately significant ...

Lions-Chiefs, Cowboys-Giants and Bills-Jets highlight a loaded Week 1 schedule By Max Molski • Published September 6, 2023 • Updated on September 11, 2023 at 8:18 pm BOOKMARKER ...

SAN FRANCISCO — The first week of the 2023 NFL season is in the rearview mirror, featuring a handful of surprising upsets, big blowouts, exciting rookie debuts, and unfortunately significant ...