The San Francisco 49ers and Detroit Lions met in last year’s NFC Championship Game. ... Each one suffered their first loss of the season after big Week 1 wins.

The NFL season is still nearly two months away, but a handful of bets for Week 1 are already gaining traction among fans.

If San Francisco is to pull off the Monday night upset, it’ll need a colossal game from its defense. Leonard Floyd leads all pass rushers with 8.5 sacks. Fred Warner is still a menace at linebacker.

This will be the first time the Lions and 49ers face off since Week 1 of the 2021 regular season, where San Francisco defeated Detroit 41-33 in the first game of the Dan Campbell, Brad Holmes era.

San Francisco 49ers quarterback Brock Purdy celebrates with tight end George Kittle after scoring a touchdown in the 49ers' 40-34 loss to the Detroit Lions in Santa Clara, California, on Monday ...

SAN FRANCISCO — The first week of the 2023 NFL season is in the rearview mirror, featuring a handful of surprising upsets, big blowouts, exciting rookie debuts, and unfortunately significant ...

Lions-Chiefs, Cowboys-Giants and Bills-Jets highlight a loaded Week 1 schedule By Max Molski • Published September 6, 2023 • Updated on September 11, 2023 at 8:18 pm BOOKMARKER ...