Longer introns, shorter exons and more complex gene organization were consistently associated with higher transcript-isoform ...

Mouse muscle subjected to mechanical overload showed extensive transcript isoform switching in adulthood, but the early ...

RNA is the means of translating the genetic code embedded in DNA into proteins, which serve as enzymes, transporters, signaling molecules, receptors, structural components, regulators, and ...

Regulation of isoforms — varied versions of RNA and proteins that can be produced from a single gene — is a critical tool in understanding brain development and genetic risk for neuropsychiatric ...

Transcript isoforms play a vital role in heath and disease, but studying them has been challenging due to limitations in traditional methods. By combining long nanopore sequencing reads with ...

A team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain. This novel dataset provides ...

Study design to create a database of transcripts, called TRAILS (TRAnscriptomic resource of Immune cells using Long-read Sequencing), from different human immune cell subsets and downstream analysis.

Northwestern Medicine scientists have developed a comprehensive atlas of genetic coding sequences in both healthy adult hearts and those with heart failure, a resource that has the potential to ...

A team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain. This novel dataset provides ...

Researchers uncovered 214,516 unique isoforms in the developing neocortex -- over 70% of which have not been previously studied. A team led by researchers at UCLA and the University of Pennsylvania ...