A new study describes the development of a cAMP analogue that specifically activates only Epac2, one of several cAMP-responsive proteins. Furthermore, the analogue activates Epac2 more potently than ...

When faced with stresses in a rapidly changing environment, bacteria must be able to sense these changes and coordinate responses rapidly. To do this, they use a number of nucleotide signalling ...

Second messengers are small molecules that transmit signals in the cell. A single second messenger typically interacts with several signalling proteins. "Even though this may give the impression of ...