Sam Francisco 49ers prepare for Week 1 against Detroit Lions. (AP Photo/Tony Avelar) ASSOCIATED PRESS. The San Francisco 49ers currently find themselves as eight-point favorites on the road ...

The San Francisco 49ers and Detroit Lions face off on Sunday in a Week 1 NFL game. Which team will get the victory? Check out these NFL Week 1 picks and predictions for the game, which can be seen ...

Despite San Francisco's Week 1 win over the Detroit Lions, injuries have popped up again. One calendar year later, and it seems to be much of the same for the San Francisco 49ers.

Dannie Rogers and Lions Legend T.J. Lang break down a key player from each team in the upcoming Week 1 matchup with the San Francisco 49ers. This is The X Factor, presented by Xfinity.

San Francisco 49ers - Detroit Lions prediction: Why the Niners will roll over Detroit in Week 1. Skip to content. All Sections. Subscribe Now. 58°F. Saturday, June 28th 2025 ...

San Francisco 49ers: A late-game swoon nearly undercut the Niners vs. the Lions, but the 49ers' success in the first 55 minutes of the game cannot be forgotten.

The Detroit Lions had an up and down day against the San Francisco 49ers, falling behind early but roaring back for a big finish in a near comeback on the afternoon. Knowing this, Week 1 was ...

Dan Campbell held his first regular-season press conference Monday as the work for Sunday's Week 1 matchup against San Francisco at Ford Field is under way in Allen Park. The Lions are conducting a ...

San Francisco 49ers vs. Detroit Lions Week 1 Preview Sep 10, 2021 Here's everything you need to know before the 49ers take on the Lions in Week 1 of the 2021 NFL season.

Here's everything you need to know before the San Francisco 49ers take on the Detroit Lions in Week 1 of the 2021 NFL season.