Panthers vs. 49ers will broadcast nationally on ESPN/ABC in Week 12 of the 2025 season. Joe Buck (play-by-play commentator), Troy Aikman (color analyst), Lisa Salters (sideline reporter) and Laura Rutledge (sideline reporter) are on the call.

The Panthers hit the road to take on the 49ers on Monday Night Football. The 49ers/Panthers game starts at 8:15 p.m. ET on ESPN. Yes! Peyton and Eli will be on ESPN2 for tonight’s 49ers/Panthers matchup.

Get the full 49ers practice and media schedule ahead of Week 13 vs. the Browns, including press conferences with Shanahan, Saleh, and Purdy

NFL Week 13 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco 49ers and Cleveland Browns.

A big stretch of games begins for the San Francisco 49ers on Sunday in Arizona against the Cardinals. Here's how to watch their Week 11 showdown.

Led by Bryce Young, the Panthers have exceeded expectations to this point in the season/ Following Sunday night’s Bics’ loss, Carolina is now tied for first in the NFC South. They also are a single game behind San Francisco for the final Wild Card spot in the playoffs.

SANTA CLARA, Calif. -- Upon welcoming quarterback Brock Purdy and receiver Ricky Pearsall back from extended injury absences on Sunday, the San Francisco 49ers viewed their Week 11 game against the Arizona Cardinals as the most important contest on their schedule.

San Francisco 49ers quarterback Brock Purdy's return should terrify the rest of the NFC, as he unlocks a different level for their offense.

The Panthers cannot beat the 49ers. Don’t misconstrue that: The Panthers can win on Monday. They have won six times already this season. But they cannot go toe-to-toe with the 49ers, both teams playing their best, and win. And that makes this game the ultimate litmus test for the Niners.