ascopubs.org

Impact of activating androgen receptor (AR) mutations on AR sensitivity to alternative ligands and response to ODM-208, a selective, first-in-class CYP11A1 inhibitor, in ...

Activation of the AKT pathway and outcomes in patients (pts) treated with or without ipatasertib (ipat) in metastatic castration-resistant prostate cancer (mCRPC): Next-generation sequencing (NGS) ...
ascopubs.org

Androgen receptor (AR) overexpression and sensitivity to hormones reversed by epigenetic therapy that restores Purα to a transcriptional repressor complex (RC) of AR ...

Evaluation of quality-of-life side effects and duration of therapy in a phase III study of intermittent monotherapy versus continuous combined androgen deprivation No significant financial ...
Science Daily

Researchers discover new mechanism for male sex hormone

Scientists have discovered a new way to boost muscle strength without the dangerous side effects of traditional androgens. A powerful male hormone called 5α-DHT normally drives bone density and muscle ...
Science Daily

Androgen receptor signaling contributes to targeted therapy resistance in melanoma

Androgen receptor (AR) signaling affects response to BRAF/MEK inhibitor therapy in both males and females with melanoma, researchers have shown. The findings provide a new target to combat therapeutic ...