Nearly 98% of the human genome does not encode proteins but comprises noncoding sequences—the “dark genome”—such as regulatory sequences that control gene transcription (enhancer elements). Thousands ...

Researchers at the Centre for Genomic Regulation (CRG) have identified a DNA sequence that is crucial for pancreatic differentiation and function – and for the first time – describe how it works.

Organisms are made up of cells, and in each of those cells, a genome encodes the instructions for that organism to grow and survive. The human genome has at least 20,000 genes, and the expression of ...

Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called ...

In a study published in Genome Research, a team of researchers, including Cornell College Assistant Professor of Biology Sophie Gillett, looked at regions of human genetic code that are known for ...

Our genomes provide the instructions for proper growth and development. Millions of genomic switches, known as enhancers, control the location and timing of gene expression, which in turn ensures the ...

Researchers at the Centre for Genomic Regulation (CRG) have identified a DNA sequence that is crucial for pancreatic differentiation and function – and for the first time – describe how it works.

The images show the abdomen of flies in which a specific enhancer region has been modified. Depending on how much and which part of the region is modified, different areas of the pigment pattern ...

Around 98.5% of human DNA is non-coding, meaning it doesn’t get copied to make proteins. A new study has connected many of these non-coding regions to the genes they affect and laid out guidelines for ...

In the vast majority of diseases caused by mutations in a single DNA sequence, the disruption of a gene is to blame. However, many non-coding elements in the genome, which inhabit what is sometimes ...